Although ultraviolet-A (UVA) is known to be a primary driver of photoaging and photocarcinogenesis, there are few available filters providing long-term protection against UVA.1 A recent study identified cannabidiol (CBD) as a promising prospective compound to mitigate damage associated with UVA exposure, noting its anti-inflammatory and antioxidant properties via regulation of NFR-2, HMOX1, and PPAR-y activity. Researchers behind the study found that topically applied nCBD cream reduced UVA-induced formation of a frequent mutagenic nuclear DNA base lesion and protected against mtDNA mutations associated with UVA-induced skin aging. This made this study the first trial to identify UV-protective capacity of CBD-containing topicals in humans.2
Adam Friedman, MD, FAAD, co-senior author on the study and chair of the department of Dermatology at The George Washington University School of Medicine and Health Sciences, told Dermatology Times, "the wealth of evidence supporting the use of CBD to manage a wide array of skin conditions has historically been at the bench, not bedside, hindering clinical translation and credibility.” Click here to read more.
